2014 May;44(5):655-70. doi: 10.1007/s40279-013-0137-7. 2023 Jan;13(1):e2820. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. and transmitted securely. 2019 Jan;98(3):e14099. J Bone Metab 2021;28(3):207-213. Ingredients such as dyes and synthetic gelatin found in gummy supplements can be difficult to digest, leading to inflammation of the gut. The participants skin hydration and elasticity also improved significantly. Please enable it to take advantage of the complete set of features! View abstract. Epub 2013 Dec 24. Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Before As a person ages and collagen production slows, bones can become weaker as the person loses the collagen necessary to keep the bones strong and supported. Kalman DS, Schwartz HI, Pachon J, Sheldon E, Almada AL. It is believed that adding more collagen to your diet could potentially cause a deficiency in tryptophan. View abstract. The ingredients list is going to be very telling when looking at any supplement., Consider if there are several additives or unnatural ingredients. 2021;20(3):825-834. Of those side effects, there has been a recurring theme among many collagen users asking: For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a, nutritional label, not a supplement label. When choosing your collagen peptides supplement, be sure its manufacturer hasnt been called out by the FDA. Its always best to speak with your doctor when beginning to take new supplements, particularly in order to avoid adverse interactions with medications. 8600 Rockville Pike View abstract. J Cosmet Dermatol. Disclaimer. Appl Physiol Nutr Metab. But these supplements are also touted to support digestion and heart health, prevent bone loss and increase muscle mass. A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase. Always take your collagen peptide supplements as instructed by a healthcare professional or as directed on the label of a product. This information may not fit your specific health circumstances. WebCollagen is a nutritional supplement made from animal or fish materials. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Collagen side effects may, for instance, be a result of excessive collagen intake. View abstract. 2010;340(5):360-6. Updated February 27, 2014. We avoid using tertiary references. Collagen and biotin may both help promote skin and hair health, but each has different pros and cons. A person should choose the supplement that best supports their goals when picking a collagen type. The participants engaged in regular exercise for 12 weeks. 2022 Nov 24;20(12):734. doi: 10.3390/md20120734. Epub 2022 Jul 23. You can learn more about how we ensure our content is accurate and current by reading our. Lin P, Alexander RA, Liang CH, et al. However, it might also help promote other areas of health, such as bone, joint, and heart health. View abstract. As tryptophan levels drop, it can impact your balance of serotonin. There were no statistically significant effects for the other dependent variables (P > 0.05). View abstract. Although rare and typically mild, side effects of collagen peptides on skin often take the form of inflammation and skin breakouts or rashes. Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study. There is some evidence to suggest that collagen supplements can help with restoring or preventing the deterioration of the cartilage in the joints. All rights reserved. Would you like email updates of new search results? Maia Campos PMBG, Melo MO, Siqueira Csar FC. Li X, He Z, Xu J, Su C, Xiao X, Zhang L, Zhang H, Li H. Foods. Others may experience constipation when they begin to integrate collagen peptides into their supplement regime, while others notice a reduction in appetite. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Int J Tissue React. While we have no reports of ProT Gold users experiencing headaches or migraines after using our collagen products, preliminary research into the topic suggests that there may be a correlation between some collagen supplements and headaches., Whether collagen can cause headaches or not often is dependent on the person taking the supplement, the dosage, the type of collagen, and the supplement quality itself., If you suspect that your supplemental collagen can cause headaches or migraines, then exploring why you have this reaction and how to prevent it will be the first place to start., Before we get into whether collagen can cause headaches, lets look at the overall safety of collagen supplements in general., If youre asking the question: can collagen cause headaches? You are probably also interested in other possible side effects of collagen, and if collagen is a safe supplement to take., Its hard to answer whether collagen can cause headaches and if the supplement itself is safe, simply because the FDA does not regulate most supplements., Since there is such limited regulation of supplements on the market, this leads to immense skepticism regarding how safe they really are and what side effects they cause., The lack of regulation when it comes to supplements versus drugs means that not all supplement companies necessarily have to prove their claims., So, if they are simply trying to sell a product to the consumer, they do not have to have evidence to support whether or not the collagen supplement they are providing actually will benefit the consumer, or whether their supplemental collagen can cause headaches or other issues., Still, the FDA does recognize ingestible collagen as Generally Recognized As Safe (GRAS)., There have been specific collagen supplements that have been recalled by the FDA for safety reasons, which is why it is important to buy from a reputable brand., For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a nutritional label, not a supplement label., Because of this, ProT Gold is also trusted by over 3,000 medical facilities and used widely for medical nutrition therapy., Something that should be recognized about collagen as a supplement is that it is natural. Curr Med Res Opin. This Theres currently 80 approved peptide drugs worldwide. J Agric Food Chem. Similar to vegan options, a person may want to look for a collagen supplement that specifically aims to support the keto diet. An official website of the United States government. View abstract. Learn about some top options here. 2022 Dec;52(12):2889-2908. doi: 10.1007/s40279-022-01718-8. These types of ingredients and additives found in supplements can also be a reason why someone gets a headache versus the collagen molecules themselves., Next, looking at the absorption rate can help you avoid other side effects like bloating or an upset stomach. 2018 Mar;78(4):411-437. doi: 10.1007/s40265-018-0865-y. It also plays a role in joint and bone health. https://webprod5.hc-sc.gc.ca/lnhpd-bdpsnh/info.do?licence=80034311&lang=eng. View abstract. 2018;13(4):438-52. Type 1: This is one of the most abundant types present in the human body and helps support healthy skin. Some peptides are antimicrobial, meaning they can kill However, such claims do not yet have scientific evidence to support them. Are they suitable for vegans and vegetarians? Kouguchi T, Ohmori T, Shimizu M, et al. anti-aging; collagen peptides; fragmentation; glycosaminoglycan; hyaluronic acid; reflectance confocal microscopy. View abstract. In one scoop of peptide powder, you typically get 10 grams of protein and 40 calories, which is not a bad trade-off. Molecules 2021;26(16):4880. This site needs JavaScript to work properly. They accomplish this by stimulating new collagen growth, in turn reducing wrinkles, boosting skin elasticity, and improving skin hydration. Porfrio, E. & Fanaro, G. B. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. Arch Dermatol. government site. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. For most people, taking collagen should not have any major effects or health consequences. Sci Rep. 2022 Jun 13;12(1):9804. doi: 10.1038/s41598-022-14068-2. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Oikawa SY, Kamal MJ, Webb EK, McGlory C, Baker SK, Phillips SM. official website and that any information you provide is encrypted Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, Knig D. Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. Int J Dermatol 2021;60(12):1449-1461. Asserin J, Lati E, Shioya T, Prawitt J. Protein and Sport: Alternative Sources and Strategies for Bioactive and Sustainable Sports Nutrition. This in turn, can lead to a number of side effects, including abnormal heart rhythms. Br J Nutr. J Neuroimmune Pharmacol. pii: E76. Czajka A, Kania EM, Genovese L, et al. Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: A systematic review. Cochrane Database Syst Rev. The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis. The role of glutamate and its receptors in migraine. From arthritis, to skin health, to post surgery healing, a quality collagen supplement can do wonders for your body. Camilion JV, Khanna S, Anasseri S, Laney C, Mayrovitz HN. Federal government websites often end in .gov or .mil. The .gov means its official. Complementary Medicine / Alternative Medicine, http://www.jmnn.org/article.asp?issn=2278-1870;year=2015;volume=4;issue=1;spage=47;epage=53;aulast=Borumand, https://www.versusarthritis.org/about-arthritis/complementary-and-alternative-treatments/types-of-complementary-treatments/collagen/, https://www.ncbi.nlm.nih.gov/pubmed/25314004, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793325/, http://www.scielo.br/pdf/rbgg/v19n1/1809-9823-rbgg-19-01-00153.pdf, https://www.ncbi.nlm.nih.gov/pubmed/23949208, https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12450, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429168/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594048/. pii: E482. Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. There are several potential health benefits that collagen supplements offer. Metabolites. 2017;42(6):588-595. View abstract. Effects of Collagen Peptides on Recovery Following Eccentric Exercise in Resistance-Trained Males-A Pilot Study. Epub 2022 Dec 1. Physiological, Pathological, and Circadian Factors Impacting Skin Hydration. View abstract. For more in-depth resources about vitamins, minerals, and supplements, visit our dedicated hub. Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, Tavi P, Sitdikova G, Giniatullin R. Int J Mol Sci. One study found that Methods: As a result, a persons skin begins to lose some of its ability to bounce back into shape, a process that many call elasticity. As this occurs, wrinkles begin to form. Bethesda, MD 20894, Web Policies To protect collagen stores, doctors recommend you use a broad-spectrum sunscreen with an SPF of 30 or higher every day, refrain from, Topical creams which include retinoic acid or, Despite the well-known risks of exposure to. Manufacturers tend to produce them using the bones and protein of animals. View abstract. Int J Sport Nutr Exerc Metab. Collagen peptide supplements can however lead to dermatological, digestive side, and other side effects, particularly in products with poorly sourced ingredients. Benefits of Circulating Human Metabolites from Fish Cartilage Hydrolysate on Primary Human Dermal Fibroblasts, an Ex Vivo Clinical Investigation for Skin Health Applications. There is some evidence to suggest that using collagen supplements may help increase muscle mass. MNT is the registered trade mark of Healthline Media. It is made up of amino acids which build our skin, connective tissue, organs, and bones and plays a role in forming the fibroblasts (cell clusters) which allow new cells to grow and replace dead ones. View abstract. The .gov means its official. Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage., The source of the collagen is also a huge factor in whether or not collagen can cause headaches and other side effects., For instance, many bone broth based collagen supplements are very high in sodium and potassium, not to mention the collagen in that type of supplement is harder to digest.. In the cosmetic industry, marine collagen is one of the most popular types, as it causes less inflammation than animal sources and is less likely to contain View abstract. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. Brain Behav. The https:// ensures that you are connecting to the 2012;7:267-273. Epub 2017 Apr 21. Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study. An official website of the United States government. 2021 Jan 1;31(1):32-39. doi: 10.1123/ijsnem.2020-0149. Lopez HL, Ziegenfuss TN, Park J. The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging. After those 8 weeks, the women who took the supplement had higher elasticity and moisture levels. Collagen supplements have the potential to cause both headaches and migraines. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. 2017;16(4):520-526. However, it is important to understand what collagen and biotin are and what research is available to support these claims. Dietary supplements do not improve bone morphology or mechanical properties in young female C57BL/6 mice. What is the latest research on the form of cancer Jimmy Carter has? Yes. Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. Results: Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Here are the 10 Best Fruits That Will Make You Poop better. While they're way gentler than retinoids are, they can still cause a rash. All rights reserved. WebCollagen is a protein responsible for healthy joints and skin elasticity, or stretchiness. Having, high levels of calcium in your blood is also known as hypercalcemia, and seems to be more predominantly an issue in women., Whether collagen can cause headaches or not is a great question to be asking, especially when trying to decide which supplements are right for you and your body. Oral Intake of Collagen Peptide Attenuates Ultraviolet B Irradiation-Induced Skin Dehydration In Vivo by Regulating Hyaluronic Acid Synthesis. Nutrients 2021;13(12):4372. There are some reports that collagen supplements may cause other digestive side effects, such as heartburn and feelings of fullness ( 21 ). View abstract. A person should always talk to their doctor before starting any new supplements or increasing the use of any existing supplement. Oliviero F, Ramonda R, Hoxha A, et al. So as you see, collagen can cause headaches and other issues in some people. The less your body has to work to break down the collagen when you consume it, the less likely you are to get a stomach ache or other unwanted side effects. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. Glutamate receptor-subtype antagonists are effective in preclinical models of migraine, and in the clinic. 2007 Aug;6(4):251-7. doi: 10.2174/187152707781387279. It is responsible for several biological functions, one of which is to provide structural support in connective tissue, muscle, and skin. 2015;14(3):30-8. Your body makes collagen naturally, but you can also consume it through collagen supplements View abstract. Conclusion: WebAutoimmune diseases (your bodys immune system attacks its own tissue) can damage collagen. Aczl T, Benczik B, gg B, Krtsi T, Urbn P, Bauer W, Gyenesei A, Tuka B, Tajti J, Ferdinandy P, Vcsei L, Blcskei K, Kun J, Helyes Z. J Headache Pain. 2013;77(4):691-6. Bookshelf 2018;16(12). J Cosmet Dermatol. Unauthorized use of these marks is strictly prohibited. Praet SFE, Purdam CR, Welvaert M, et al. Bone mineral density is key to preventing bone fractures. The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial. However, it is possible to have too much of a good thing., If calcium is the cause of your collagen-related headache problems, then a simple change in collagen supplement dosage may be in order to reduce the likelihood that your collagen can cause headaches., If you are worried about or already are experiencing headaches from your collagen supplements then it is best to consult a medical professional. Maia Campos PMBG, Melo MO, Siqueira Csar FC. Biosci Rep. 2018 Dec 14;38(6):BSR20181347. View abstract. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90. Oral collagen supplements also increase skin elasticity, hydration, and dermal collagen density. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. Effects of protein supplements on muscle damage, soreness and recovery of muscle function and physical performance: a systematic review. Apweiler E, Wallace D, Stansfield S, Allerton DM, Brown MA, Stevenson EJ, Clifford T. Sports (Basel). However, some of the potential health benefits of collagen supplements include: Some people who take collagen supplements are looking to improve the look and overall health of their skin. Creams have the advantage of providing extra hydration, making them particularly suitable for dry, wrinkled, or aging skin, and they pose even fewer risks than the already rare potential side effects of oral supplements. Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. A 2016 animal study also found that collagen hydrolysate (also called collagen peptides) reduced fat cell size and weight gain in rats. View abstract. J Sports Sci Med. WebCollagen peptides are made by breaking down whole collagen proteins into smaller pieces. Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Human bodies create collagen naturally. View abstract. doi: 10.1042/BSR20181347. 8600 Rockville Pike The .gov means its official. Collagen is a protein that promotes skin elasticity. The protein collagen has 3 essential amino acids that decrease constipation, helps with leaky gut syndrome, and even reduces diarrhea. View abstract. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. The https:// ensures that you are connecting to the The takeaway Peptides are amino acids that are the building blocks of certain proteins needed by the skin, like collagen and elastin. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Elam ML, Johnson SA, Hooshmand S, et al. Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study. Semin Arthritis Rheum. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. When taken by mouth, collagen peptides seem to build up in the skin and cartilage. Urinary Hydroxyproline Is Only Suitable As a Biomarker for Acute Intake, Up to 6 hr Postingestion of Collagen Proteins in "Free-Living," Healthy, Active Males. Having high levels of calcium in your blood is also known as hypercalcemia and seems to be more predominantly an issue in women., Too much calcium can also cause some skin rashes and other symptoms overlapping with side effects with collagen., One way to determine if calcium is the cause of your headaches or if taking a collagen supplement is raising your blood calcium levels is to get a blood test for calcium. The animal ingredients commonly found in collagen peptide supplements can be extraordinarily high in calcium, which, in come cases can lead to hypercalcemia. Lim, S. H., Sun, Y., Thiruvallur Madanagopal, T., Rosa, V., & Kang, L. (2018). This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2014;39(8):874-80. Many people know collagen for its role in supporting skin health and vitality. The https:// ensures that you are connecting to the Collagen Facility offers easy-to-digest hydrolyzed collagen peptides. WebYes, collagen does make you poop more! In conclusion, CP had moderate benefits for the recovery of CMJ and muscle soreness but had no influence on inflammation and bone collagen synthesis. government site. View abstract. Bethesda, MD 20894, Web Policies Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification. This is typically due to additives, preservatives, heavy metals, or poorly sourced animal products included as ingredients in certain supplements. Collagen is the protein responsible for skin elasticity. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. But does collagen have any side effects, and can collagen cause headaches?. By following these tips, you can help ensure safe use of collagen peptides powder and minimize the risk of side effects or health issues. Many are available to buy online. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). View abstract. However, it is important to understand what collagen and biotin are and what research is available to support these claims. When applied topically or ingested, products containing collagen peptides signal to your body that it needs to produce more collagen. The answer is yes., a study published in the Journal of the American Medical Association, found that people who took collagen-based View abstract. 2015;14(4):291-301. WebMD does not provide medical advice, diagnosis or treatment. 2017 Dec 14;12(12):CD009789. If you have allergies, make sure to purchase supplements that arent made from collagen sources youre sensitive to. Potential Cosmetic Active Ingredients Derived from Marine By-Products. Sugihara F, Inoue N, Venkateswarathirukumara S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial.